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Your babys little giggles, little steps, and little sniffles. Being there with a little hug and a little song. Loving touches and attention to detail go into everything you do. Little things matter to us, too. Little Remedies designs safe and reliable solutions just for babies. To help your baby stay happy, we make sure they have everything they need and nothing they dont. *IQVIA, using the ProVoice Survey, from December 1, 2018 to November 30, 2019. 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This Green colored packet will make a Hypertonic (higher concentration) solution when mixed with 8 oz. (240 ml.) of water. It can also make an isotonic solution, equivalent to our regular blue colored packet, if mixed with 16 oz. (480 ml.) of water. Our regular product, the blue colored packet, makes an isotonic solution in 8 oz. (240 ml.) of water (using our SINUS RINSE bottle or other measuring devices). It is strongly recommended to use this Green packet only under the advice of your physician or using your judgment. A few research reports, plus feedback from some physicians and customers have reported additional benefits from using a hypertonic solution. If you experience any intolerable burning or stinging, please discontinue the use of the hypertonic solution. In my opinion, apart from transient, mild burning, it will not cause any permanent damage with a few uses. With time, you will be able to judge as far as what concentration of saline works best for you. 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